Of the comparing the fresh differential development out-of gene losings rather than gain between the latest GATA paralogons inside and you may of the vertebrate types, i infer the fresh new evolutionary beginning order of one’s GATA paralogons by the deciding more parsimonious trend out of ohnolog maintenance (Numbers 4, 5, 6a, 7a). In this research, i establish clade-specific protected losings off repeated paralogs, though it is even officially possible that this type of ‘losses’ get show the fresh translocation regarding good pre-replication gene to the otherwise away from good paralogon ahead of a great gene duplication skills. However, all the times is actually phylogenetically academic.

Towards GATA123 family (Profile 6a), i end the 1st 1R replication of ancestral GATA123 paralogon made an excellent GATA1/1-ogm (ohnolog went missing, discover ) and you can an excellent GATA2/step three paralogon, and you may is actually followed closely by seven further paralogous gene losses. Lire la suite